Location and function of critical genes in leukemogenesis inferred from cytogenetic abnormalities in hematologic malignancies
Identifieur interne : 000125 ( France/Analysis ); précédent : 000124; suivant : 000126Location and function of critical genes in leukemogenesis inferred from cytogenetic abnormalities in hematologic malignancies
Auteurs : Olivier A. Bernard [France]Source :
- Seminars in Hematology [ 0037-1963 ] ; 2000.
English descriptors
- Entity :
- pers : Based, Dramatic, Juliette Dodu, Paris Conference, Rohnd, Roland Berger, Table.
- place : France, Paris.
- Teeft :
- Abnormality, Acute leukemia, Acute lymphoblastic leukemia, Acute myeloid leukemia, Acute promyelocytic leukemia, Amll, Amll gene, Balanced reciprocal translocation, Binding domain, Biol, Breakpoint, Breakpoints, Cell biol, Chromosomal, Chromosomal breakpoints, Chromosomal translocation, Chromosome, Chromosome abnormality, Chromosome rearrangement, Critical gene, Deacetylase, First example, Functional consequence, Fusion protein, Gene, Gene identification, Genet, Hematopoietic, Hematopoietic malignancy, Histone deacetylase, Human chromosome, Leukemia, Leukemogenesis, Locus, Malignancy, Malignant cell, Malignant process, Molecular analysis, Molecular basis, Myeloid, Myeloid leukemia, Myeloid malignancy, Partner chromosome, Partner gene, Partner protein, Proc natl acad, Promiscuous gene, Promyelocytic, Rearrangement, Recurrent translocation, Retinoic acid, Runt domain, Several partner gene, Transcription, Transcription factor, Transcriptional, Translocation, Translocation breakpoints, Trend genet, Tyrosine kinase.
Abstract
Abstract: Dramatic advances in the cytogenetic analysis of chromosomal rearrangements of hematopoietic malignancies have occurred over the past years. These are due to considerable improvement in the techniques of molecular cytogenetics. Various applications of fluorescence in situ hybridization (FISH), used in conjunction with conventional cytogenetics, make the recognition of some abnormalities easier, and the localization of chromosomal breakpoints in structural rearrangements more precise. Under many circumstances, accurate breakpoint localization is the first step toward the identification of genes involved in translocations and inversions. Some of the genes recently discovered may be rearranged with several partner genes. These promiscuous genes are natural experiments that generate mutants which help to identify the function of genes rearranged in hematopoietic malignancies as well as that of their normal counterparts. The diversity of the genes implicated in leukemogenesis makes their functional study a challenge, but, as recently shown by their role in chromatin remodeling, increasing recognition of cross-talk between many of these genes justifies the development of analyses of leukemia-associated chromosome abnormalities and of their functional consequences.
Url:
DOI: 10.1016/S0037-1963(00)90020-9
Affiliations:
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Bernard</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>From INSERM U434 and CNRS SD 401 No. 434, Institut de Génétique Moléculaire, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Seminars in Hematology</title><title level="j" type="abbrev">YSHEM</title><idno type="ISSN">0037-1963</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="412">412</biblScope><biblScope unit="page" to="419">419</biblScope></imprint><idno type="ISSN">0037-1963</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0037-1963</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Entity" type="pers" xml:lang="en"><term>Based</term><term>Dramatic</term><term>Juliette Dodu</term><term>Paris Conference</term><term>Rohnd</term><term>Roland Berger</term><term>Table</term></keywords><keywords scheme="Entity" type="place" xml:lang="en"><term>France</term><term>Paris</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term><term>Acute leukemia</term><term>Acute lymphoblastic leukemia</term><term>Acute myeloid leukemia</term><term>Acute promyelocytic leukemia</term><term>Amll</term><term>Amll gene</term><term>Balanced reciprocal translocation</term><term>Binding domain</term><term>Biol</term><term>Breakpoint</term><term>Breakpoints</term><term>Cell biol</term><term>Chromosomal</term><term>Chromosomal breakpoints</term><term>Chromosomal translocation</term><term>Chromosome</term><term>Chromosome abnormality</term><term>Chromosome rearrangement</term><term>Critical gene</term><term>Deacetylase</term><term>First example</term><term>Functional consequence</term><term>Fusion protein</term><term>Gene</term><term>Gene identification</term><term>Genet</term><term>Hematopoietic</term><term>Hematopoietic malignancy</term><term>Histone deacetylase</term><term>Human chromosome</term><term>Leukemia</term><term>Leukemogenesis</term><term>Locus</term><term>Malignancy</term><term>Malignant cell</term><term>Malignant process</term><term>Molecular analysis</term><term>Molecular basis</term><term>Myeloid</term><term>Myeloid leukemia</term><term>Myeloid malignancy</term><term>Partner chromosome</term><term>Partner gene</term><term>Partner protein</term><term>Proc natl acad</term><term>Promiscuous gene</term><term>Promyelocytic</term><term>Rearrangement</term><term>Recurrent translocation</term><term>Retinoic acid</term><term>Runt domain</term><term>Several partner gene</term><term>Transcription</term><term>Transcription factor</term><term>Transcriptional</term><term>Translocation</term><term>Translocation breakpoints</term><term>Trend genet</term><term>Tyrosine kinase</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Dramatic advances in the cytogenetic analysis of chromosomal rearrangements of hematopoietic malignancies have occurred over the past years. These are due to considerable improvement in the techniques of molecular cytogenetics. Various applications of fluorescence in situ hybridization (FISH), used in conjunction with conventional cytogenetics, make the recognition of some abnormalities easier, and the localization of chromosomal breakpoints in structural rearrangements more precise. Under many circumstances, accurate breakpoint localization is the first step toward the identification of genes involved in translocations and inversions. Some of the genes recently discovered may be rearranged with several partner genes. These promiscuous genes are natural experiments that generate mutants which help to identify the function of genes rearranged in hematopoietic malignancies as well as that of their normal counterparts. The diversity of the genes implicated in leukemogenesis makes their functional study a challenge, but, as recently shown by their role in chromatin remodeling, increasing recognition of cross-talk between many of these genes justifies the development of analyses of leukemia-associated chromosome abnormalities and of their functional consequences.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Bernard, Olivier A" sort="Bernard, Olivier A" uniqKey="Bernard O" first="Olivier A" last="Bernard">Olivier A. Bernard</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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